Including Hiv.........................................................................................................................7
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Characterization of Immune Responses Induced by Combined Clade-A HIV-1 Recombinant Adenovectors in Mice
Background: Numerous evidences indicate that in some HIV-1 positive patients, the humoral and cellular immune responses are induced against HIV-1 proteins and this is inversely related to the progress of infection. Objective: The aim of this study was the evaluation of the Adenovectors containing HIV genes in induction of immune responses in mice. Methods: The HIV-1 genes including gag p24, rev...
متن کاملHIV-Derived Lentiviral Vectors: Current Progress toward Gene Therapy and DNA Vaccination
Lentiviral vectors are promising gene delivery tools capable of transducing a variety of dividing and non-dividing cells, including pluripotent stem cells which are refractory for transduction by murine retroviruses. Although there is a growing debate on the safety of lentiviral vectors for gene transfer, in particular for those derived from human immunodeficiency viruses, type one (HIV-1) and ...
متن کاملCoping with Stress Strategies among HIV Positive Patients: A Qualitative Content Analysis
Background and Objectives: Patients with HIV/AIDS have different experiences regarding coping with stress. Understanding these experiences is essential to design tailored interventions. The aim of this study was to explore experiences of patients with HIV on coping with stress strategies. Materials and Methods: In this qualitative content analysis study, 26 participants with HIV were selected u...
متن کاملIL-7 Promotes CD95-Induced Apoptosis in B Cells via the IFN-γ/STAT1 Pathway
Interleukin-7 (IL-7) concentrations are increased in the blood of CD4+ T cell depleted individuals, including HIV-1 infected patients. High IL-7 levels might stimulate T cell activation and, as we have shown earlier, IL-7 can prime resting T cell to CD95 induced apoptosis as well. HIV-1 infection leads to B cell abnormalities including increased apoptosis via the CD95 (Fas) death receptor pathw...
متن کاملHIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro.
We report a novel mechanism, involving up-regulation of the interleukin (IL)-7 cytokine receptor, by which human immunodeficiency virus (HIV) enhances its own production in monocyte-derived macrophages (MDM) in vitro. HIV-1 infection or treatment of MDM cultures with exogenous HIV-1 Tat(86) protein up-regulates the IL-7 receptor (IL-7R) alpha-chain at the levels of steady-state RNA, protein, an...
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